Quartzville Creek is a tributary of the Middle Santiam River in Linn County in Oregon. It is paralleled by the Quartzville Back Country Byway and used for recreation, including camping, fishing, hunting, kayaking, and gold panning. The creek is beginning at an elevation of about 4,100 feet between Pinnacle and Gordon peaks in the Cascade Range, flows generally west and southwest through Willamette National Forest. In its upper reaches, it receives Butte and Bruler creeks from the right, Freeze out Creek from the left, Beabe Creek from the left, Little Meadows Creek from the right, Gregg and McQuade creeks from the left, then Gold Creek from the right. In the next stretch, Green, Savage, and Galena creeks enter from the left. Below Galena Creek, Quartzville Creek leaves the national forest and Canal Creek enters from the right. One of Canal Creek's tributaries, Dry Gulch, drains the former Quartzville town site for which Quartzville Creek is named. Continuing generally southwest, the creek receives Trout Creek and Moose Creek from the right as it enters a northern arm of Green Peter Reservoir. Foots Canyon is which drains part of Green Peter Peninsula, enters from the left before the creek reaches Whitcomb Creek Park, on the right. Downstream of Canal Creek, the creek is followed on the right by Quartzville Road. Along this stretch, yellow bottom Creek enters from the right at Yellow bottom Campground. Shortly thereafter, the creek turns sharply south and receives Packers Gulch from the right.